BDBM50341008 4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-acetyl]-[1,4]diazepane-1-carboxylic acid(5-tert-butyl-isoxazol-3-yl)-amide::CHEMBL1762427

SMILES CC(C)(C)c1cc(NC(=O)N2CCCN(CC2)C(=O)CN2CCS(=O)(=O)CC2)no1

InChI Key InChIKey=IWGWKANZPRNVTJ-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50341008   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341008(4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ace...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 using flourescent probe 7-benzyloxyquinoline and 7-benzyloxy-4-(trifluoromethyl)-coumarin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341008(4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ace...)
Affinity DataEC50:  107nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341008(4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ace...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 using flourescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341008(4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ace...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 flourescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341008(4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ace...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB1 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed