BDBM50342615 CHEMBL1770560::N-((6S,9R)-6-(2,3-difluorophenyl)-2-(hydroxymethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide

SMILES OCc1cn2C[C@@H](CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)c2n1)c1cccc(F)c1F

InChI Key InChIKey=PWKAMDVVLHKJMA-IIBYNOLFSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342615   

TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342615(CHEMBL1770560 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342615(CHEMBL1770560 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342615(CHEMBL1770560 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed