BDBM50342916 6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine::CHEMBL1474834

SMILES CN(Cc1csc(C)n1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1

InChI Key InChIKey=PMDAVRLCSZSLRH-UHFFFAOYSA-N

Data  6 IC50  13 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50342916   

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  190nMAssay Description:Binding affinity to human Ysk4 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  340nMAssay Description:Binding affinity to human PIK3C2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  360nMAssay Description:Binding affinity to human PIP5K2C More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  370nMAssay Description:Binding affinity to human PIK3CG More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 15(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  430nMAssay Description:Binding affinity to human Erk8 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  480nMAssay Description:Binding affinity to human Dyrk2 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human Clk4 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  13nMAssay Description:Binding affinity to human Dyrk1A More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  18nMAssay Description:Binding affinity to human Clk1 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  40nMAssay Description:Binding affinity to human PIK3C2GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  47nMAssay Description:Binding affinity to human Mek5 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  59nMAssay Description:Binding affinity to human Clk2 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataIC50:  186nMAssay Description:Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human Dyrk1B More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed