BDBM50343424 1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL406658

SMILES Fc1ccc(CNc2ncnc3n(CC(Cl)c4ccc(Cl)cc4)ncc23)cc1

InChI Key InChIKey=QNYNFUREPOMYSY-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50343424   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataKi:  80nMAssay Description:Binding affinity to human recombinant Abl by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataKi:  80nMAssay Description:Binding affinity to recombinant wild type human Abl using abitide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant c-Abl by filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataKi:  800nMAssay Description:Inhibition of human recombinant c-Src by filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of Abl kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343424(1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobe...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed