BDBM50346295 CHEMBL1782375::cis-((1S,3R)-3-(hexahydropyrano[4,3-b]pyrrol-1(6H)-yl)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone

SMILES CC(C)[C@@]1(CC[C@H](C1)N1CCC2COCCC12)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F

InChI Key InChIKey=PHDISVGKDQNAFO-UXUZRQAQSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50346295   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  23.8nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  23.8nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  135nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  9.5nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346295(CHEMBL1782375 | cis-((1S,3R)-3-(hexahydropyrano[4,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed