BDBM50346298 CHEMBL1782566::cis-((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridin-3-yl)piperazin-1-yl)methanone

SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCN(CC1)c1cncc(c1)C(F)(F)F

InChI Key InChIKey=GAAFVUXDDNGWFO-SPHCQZIESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50346298   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346298(CHEMBL1782566 | cis-((1S,3R)-1-isopropyl-3-((3S,4S...)
Affinity DataIC50:  2.10E+3nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346298(CHEMBL1782566 | cis-((1S,3R)-1-isopropyl-3-((3S,4S...)
Affinity DataIC50:  40.1nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346298(CHEMBL1782566 | cis-((1S,3R)-1-isopropyl-3-((3S,4S...)
Affinity DataIC50:  15.6nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed