BDBM50350021 CHEMBL1813067

SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1

InChI Key InChIKey=XUKROCVZGZNGSI-CQSZACIVSA-N

Data  18 KI  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50350021   

TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NAMH from human H3R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  2.70nMAssay Description:Antagonist activity at histamine H3 receptor in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]NAMH from rat H3R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]NAMH from rat cloned histamine 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]NAMH from rat histamine H3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of adrenergic alpha 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of norepinephrine transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of recombinant human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibition of recombinant human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataEC50:  2nMAssay Description:Inverse agonist activity at rat histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataEC50:  1.10nMAssay Description:Inverse agonist activity at human histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of recombinant human ERG channel expressed in human HEK 293 cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50350021(CHEMBL1813067)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed