BDBM50363773 CHEMBL1945137::US9365508, 331a (4-isopropyl)

SMILES CC(C)c1ccc(cc1)C(=O)NC(=S)Nc1ccc(NC(=O)CCCCN(C)C)cc1

InChI Key InChIKey=UTQHGPPEEJLEOE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50363773   

TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  6.48E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of St. Andrews

Curated by ChEMBL
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  5.71E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  4.27E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of St. Andrews

Curated by ChEMBL
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  3.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In DepthDetails US Patent