BDBM50372868 CHEMBL404886

SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnn1

InChI Key InChIKey=HHKGHOHNMXZGJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50372868   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50372868(CHEMBL404886)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50372868(CHEMBL404886)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50372868(CHEMBL404886)
Affinity DataIC50:  5.00E+3nMAssay Description:Displacement of [3H]-L-AP4 from rat mGluR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed