BDBM50379138 CHEMBL2012951

SMILES Cc1nc2c(OC(F)F)cccc2n1-c1ccc(s1)C(=O)NC1CC1

InChI Key InChIKey=VQQZSOVXMSWVFT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50379138   

TargetCytochrome P450 1A2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP1A2 using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human DHODH after 20 mins by 2,6-dichloroindophenol-reduction based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C9 using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50:  2.88E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379138(CHEMBL2012951)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C19 using S-mephenytoin as substrate after 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed