BDBM50382693 CHEMBL2023159::US9409868, 25

SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1

InChI Key InChIKey=DXROFJODNNFSMZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50382693   

TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50382693(CHEMBL2023159 | US9409868, 25)
Affinity DataIC50:  2.61E+3nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50382693(CHEMBL2023159 | US9409868, 25)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50382693(CHEMBL2023159 | US9409868, 25)
Affinity DataIC50:  2.61E+3nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50382693(CHEMBL2023159 | US9409868, 25)
Affinity DataIC50:  1.98E+4nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails US Patent