BDBM50388980 CHEMBL2063880

SMILES CN1CCN(CCCNC(=O)c2c(c(cn2CC[C@H](O)CO)-c2ccc(Cl)cc2)-c2ccccc2)CC1

InChI Key InChIKey=DXJMWRCEEVNUJU-VWLOTQADSA-N

Data  4 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50388980   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataKi:  7.80E+4nMAssay Description:Binding affinity to N-terminus 6X His-tagged human Bcl2 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataKi:  1.38E+5nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataKi:  1.38E+5nMAssay Description:Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataKi:  1.38E+5nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataIC50:  4.53E+5nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataIC50:  2.13E+5nMAssay Description:Binding affinity to N-terminus 6X His-tagged human Bcl2 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataIC50:  4.53E+5nMAssay Description:Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal His8-tagged Mcl1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BID binding aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50388980(CHEMBL2063880)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Mcl1 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed