BDBM50404281 CHEMBL2111784

SMILES C[C@H](Nc1cc(ccn1)-c1sc(nc1-c1ccc(F)cc1)C1CCN(C)CC1)c1ccccc1

InChI Key InChIKey=HJEPFPDXSFKWQH-IBGZPJMESA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50404281   

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  280nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Met proto-oncogene tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  261nMAssay Description:Inhibition of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human Epidermal growth factor receptor, HER-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human c-Kit kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  18nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human c-Jun N-terminal kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  700nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed