BDBM50418083 CHEMBL1743359::ZILEUTON

SMILES C[C@@H](N(O)C(N)=O)c1cc2ccccc2s1

InChI Key InChIKey=MWLSOWXNZPKENC-SSDOTTSWSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50418083   

TargetCytochrome P450 1A2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50418083(CHEMBL1743359 | ZILEUTON)
Affinity DataKi:  6.60E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 1A2 measured by phenacetin O-deethylation (POD) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50418083(CHEMBL1743359 | ZILEUTON)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant human LOX5 using arachidonic acid as substrate preincubated for 5 mins prior to substrate addition measured for 4 mins by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50418083(CHEMBL1743359 | ZILEUTON)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of soybean LOX1 assessed as reduction in linoleic acid oxidation measured every 10 s for 10 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed