BDBM50420303 CHEMBL2089064::US8598217, 135

SMILES CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccnc(c1)-c1cncc2ccccc12

InChI Key InChIKey=VSHURSPEQITHNX-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420303   

TargetCyclin-dependent kinase 4(Oryctolagus cuniculus (Rabbit))
Astex Therapeutics

US Patent
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50:  12nMpH: 7.5Assay Description:A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50:  300nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assayMore data for this Ligand-Target Pair