BDBM50425780 CHEMBL2316582

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=TZKBVRDEOITLRB-UHFFFAOYSA-N

Data  6 IC50  2 Kd

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50425780   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to phosphorylated wild type ABL1 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataKd:  0.320nMAssay Description:Binding affinity to nonphosphorylated wild type ABL1 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of His tagged recombinant human FGFR1 (308 to 731 residues) expressed in baculovirus expression system incubated for 1.5 hrs in the presen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant CYP2C9 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of His tagged recombinant human FLT3 (564 to 958 residues) expressed in baculovirus expression system incubated for 1.5 hrs in the presenc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PDGFRalpha (unknown origin) incubated for 1.5 hrs in the presence of ATP by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50:  990nMAssay Description:Inhibition of human recombinant CYP2C19 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed