BDBM50426931 CHEMBL2323729::US20230365568, Compound 6a

SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O

InChI Key InChIKey=IYLBMSHZRRWSRM-FALOATQWSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50426931   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of HA-EGFP tagged Plk1 polo-box domain (unknown origin) expressed in 293A cells assessed as inhibition of biotin-p-T78 binding after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of Plk1 polo-box domain in human HeLa cells/biotin-GGGGG-PLHSpT interaction incubated for 30 mins measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  1.47E+4nMAssay Description:An ELISA-based PBD-binding inhibition assay was performed essentially as described previously. Briefly, a biotinylated PBIP1 p-T78 peptide (i.e., Bio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  3.68E+4nMAssay Description:Inhibition of Plk1-PBD in HEK293A cells expressing HA-EGFP-Plk1 using 3,3',5,5'-tetramethylbenzidine substrate solution as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50426931(CHEMBL2323729 | US20230365568, Compound 6a)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of FITC-Ahx-DPPLHSpTAI-NH2 binding to Plk1 PBD (unknown origin) expressed in bacterial expression system measured after 30 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed