BDBM50430934 CHEMBL2336944

SMILES OC(=O)COc1ccc(Br)cc1C=c1c(=C)[nH]n(-c2ccc(Cl)c(Cl)c2)c1=O

InChI Key InChIKey=OSPAEDWIQLTHSC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50430934   

TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50430934(CHEMBL2336944)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of PGES-1 in human whole blood assessed as LPS-induced PGE2 formation incubated for 15 mins prior to LPS addition measured after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50430934(CHEMBL2336944)
Affinity DataIC50:  170nMAssay Description:Inhibition of full-length microsomal PGES-1 (unknown origin) expressed in Escherichia coli Rosetta(DE3) using PGH2 as substrate assessed as inhibitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed