BDBM50430938 CHEMBL2336520

SMILES CCOC(=O)C1=C(C)N=c2s\c(=C/c3ccc(o3)-c3ccc(Cl)c(c3)C(O)=O)c(=O)n2C1c1ccccc1Cl

InChI Key InChIKey=TZMXXBNAGWGOMD-XKZIYDEJSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50430938   

TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50430938(CHEMBL2336520)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of PGES-1 in human whole blood assessed as LPS-induced PGE2 formation incubated for 15 mins prior to LPS addition measured after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50430938(CHEMBL2336520)
Affinity DataIC50:  2nMAssay Description:Inhibition of full-length microsomal PGES-1 (unknown origin) expressed in Escherichia coli Rosetta(DE3) using PGH2 as substrate assessed as inhibitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed