BDBM50435357 CHEMBL2391582::US11279687, Compound 94
SMILES Fc1cccc(CNC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCCCC2)c1
InChI Key InChIKey=UGERNPMSSMEKOE-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50435357
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 5 uM NAMMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 1 uM NAMMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 250 uM NAMMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 121nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 25 uM NAMMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of Nampt (unknown origin) using NAM/PRPP as substrate preincubated for 15 mins measured after 30 minsMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 756nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 125 uM NAMMore data for this Ligand-Target Pair