BDBM50435358 CHEMBL2391591

SMILES O=C(COc1cccnc1)Nc1ccc(cc1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=FVYHXZWAUONRPT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50435358   

TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  33nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 5 uM NAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  27nMAssay Description:Inhibition of Nampt (unknown origin) using NAM/PRPP as substrate preincubated for 15 mins measured after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  82nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 25 uM NAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  1.21E+3nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 250 uM NAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  476nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 125 uM NAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435358(CHEMBL2391591)
Affinity DataIC50:  12nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 1 uM NAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed