BDBM50438882 10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (5)::CHEMBL471342

SMILES O=c1nc2n(-c3ccccc3)c3ccccc3cc2c(=O)[nH]1

InChI Key InChIKey=BBWFTVFLVHVBCD-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50438882   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TDP2 (unknown origin) using 5'-Y-TCCGTTGAAGCCTGCTTT-3' as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50:  7.10E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Rattus norvegicus)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >3.45E+5nMAssay Description:Inhibition of rat brain protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mus musculus (Mouse))
National Institutes of Health

LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes of Health

LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50:  7.10E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50:  2.00E+4nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed