BDBM50442991 CHEMBL432537::GNF-Pf-3777::US10669273, Compound 5i

SMILES [O-][N+](=O)c1ccc-2c(c1)C(=O)c1nc3ccccc3c(=O)n-21

InChI Key InChIKey=UFMQJYHLIUACCG-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50442991   

TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataKi:  970nMAssay Description:Uncompetitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed