BDBM50446246 CHEMBL3109192::US9732037, Compound 12
SMILES Cc1cc(N)nc(CO[C@H]2CN[C@H](COCCOCc3cccc(F)c3)C2)c1
InChI Key InChIKey=HBLUENCDTVSVQJ-AZUAARDMSA-N
Data 6 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50446246
Affinity DataKi: 153nMAssay Description:Inhibition of rat recombinant nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex mea...More data for this Ligand-Target Pair
Affinity DataKi: 153nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
Affinity DataKi: 5.86E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 5.86E+3nMAssay Description:Inhibition of mouse recombinant iNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex m...More data for this Ligand-Target Pair
Affinity DataKi: 7.96E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 7.96E+3nMAssay Description:Inhibition of bovine recombinant eNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex ...More data for this Ligand-Target Pair