BDBM50446903 CHEMBL3115293

SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1

InChI Key InChIKey=WQCGQOGFMYLPHX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50446903   

TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50446903(CHEMBL3115293)
Affinity DataIC50:  1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50446903(CHEMBL3115293)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50446903(CHEMBL3115293)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed