BDBM50447177 CHEMBL3113167::US10752581, Compound 37

SMILES COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3[nH]2)c1O

InChI Key InChIKey=KRAHWYARTAFAAJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50447177   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50: >3.50E+4nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human epithelial 15-LOX2 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Eastern Virginia Medical School

US Patent
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50: >7.00E+4nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50:  570nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50:  570nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Eastern Virginia Medical School

US Patent
LigandPNGBDBM50447177(CHEMBL3113167 | US10752581, Compound 37)
Affinity DataIC50: >7.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed