BDBM50447519 CHEMBL3115906

SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#7]-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7]

InChI Key InChIKey=HBSORMIZGCNHGO-LEWJYISDSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447519   

TargetVitamin K-dependent protein C(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50447519(CHEMBL3115906)
Affinity DataKi:  800nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50447519(CHEMBL3115906)
Affinity DataKi: >1.90E+4nMAssay Description:Competitive inhibition of human coagulation factor 11a using S-2366 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50447519(CHEMBL3115906)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50447519(CHEMBL3115906)
Affinity DataIC50: >4.40E+4nMAssay Description:Inhibition of human coagulation factor 11a using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed