BDBM50460700 CHEMBL4227812

SMILES COc1ccc(Nc2nccc(NC(=O)Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1

InChI Key InChIKey=IZXAWICOIQJFFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50460700   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460700(CHEMBL4227812)
Affinity DataIC50:  391nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460700(CHEMBL4227812)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460700(CHEMBL4227812)
Affinity DataIC50:  348nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed