BDBM50460824 CHEMBL4063514::US11116757, No. A68

SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=IEHVAXVEGOKCRG-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460824   

TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50460824(CHEMBL4063514 | US11116757, No. A68)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50460824(CHEMBL4063514 | US11116757, No. A68)
Affinity DataEC50:  180nMAssay Description:Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460824(CHEMBL4063514 | US11116757, No. A68)
Affinity DataIC50:  480nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460824(CHEMBL4063514 | US11116757, No. A68)
Affinity DataIC50:  480nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460824(CHEMBL4063514 | US11116757, No. A68)
Affinity DataIC50:  488nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent