BDBM50465359 CHEMBL4279052::US10669276, Example 11

SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cc(C)nc2C)nc2N(CC(C)(C)c12)c1ccc(F)cc1

InChI Key InChIKey=IKJZUNNQQQRVRP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50465359   

TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50465359(CHEMBL4279052 | US10669276, Example 11)
Affinity DataEC50:  33nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50465359(CHEMBL4279052 | US10669276, Example 11)
Affinity DataEC50:  33nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed