BDBM50465439 CHEMBL4277760

SMILES Cc1cc(cc(C)c1Oc1nc(NC2CCN(Cc3ccc(cc3)S(N)(=O)=O)CC2)nc2cc[nH]c12)C#N

InChI Key InChIKey=XVUDRALPLQPOCV-UHFFFAOYSA-N

Data  1 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50465439   

TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  4nMAssay Description:Inhibition of HIV1 reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  4.80nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  18nMAssay Description:Inhibition of HIV1 RES056 reverse transcriptase F227L/V106A double mutant infected in human MT4 cells assessed as protection against virus-induced cy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  85nMAssay Description:Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  7.20nMAssay Description:Inhibition of HIV1 reverse transcriptase Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataIC50:  75nMAssay Description:Inhibition of wild-type HIV1 reverse transcriptase infected in human MT4 cells assessed as reduction in biotin-dUTP incorporationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  4.20nMAssay Description:Inhibition of HIV1 reverse transcriptase L100I mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465439(CHEMBL4277760)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed