BDBM50503500 CHEMBL4451430::US10626103, Example 62

SMILES COc1ccc(cc1F)-n1c(C)c(nc1-c1ccc(C#N)c(F)c1)C(=O)N[C@@H]1CCCNC1

InChI Key InChIKey=GRPRTGZMLPXPGO-QGZVFWFLSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503500   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503500(CHEMBL4451430 | US10626103, Example 62)
Affinity DataIC50:  5nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503500(CHEMBL4451430 | US10626103, Example 62)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503500(CHEMBL4451430 | US10626103, Example 62)
Affinity DataEC50:  22nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed