BDBM50506482 CHEMBL4547257::US11311527, Cpd ID I-1::US11376246, Cpd ID I-1::US11576906, Compound I-1

SMILES Cn1c(ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c1=O)C#N

InChI Key InChIKey=PDMDNRKCRBOWOM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50506482   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human Myc-DDK-tagged IDH1 R132H mutant using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  55nMAssay Description:Please see paper.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  55nMAssay Description:Compound 1 was not initially reported as having the greatest biochemical potency compared to reports for certain other small molecule inhibitors of m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  55nMAssay Description:The cellular potency of Compound 1 in suppressing intracellular 2-HG levels was determined in cell lines expressing five different mutated IDH-1 prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  5.30E+3nMAssay Description:The cellular potency of Compound 1 in suppressing intracellular 2-HG levels was determined in cell lines expressing five different mutated IDH-1 prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM50506482(CHEMBL4547257 | US11311527, Cpd ID I-1 | US1137624...)
Affinity DataIC50:  5.30E+3nMAssay Description:Please see paper.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent