BDBM50521571 CHEMBL4464990

SMILES Fc1cc2[C@H](CCOc2cc1S(=O)(=O)Nc1ccncn1)N1CC[C@@H](C[C@@H]1c1ccccn1)C(F)(F)F

InChI Key InChIKey=XQUOWYVEKSXNET-RYGJVYDSSA-N

Data  1 KI  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50521571   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]GX-545 from full length human Nav1.7 VSD4 domain expressed in HEK cell membranes measured after 20 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd:  0.380nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.1 expressed in CHO cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd:  12nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd:  33nMAssay Description:Inhibition of full length rat Nav1.7 at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.5 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.3 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd:  29nMAssay Description:Inhibition of full length human Nav1.6 expressed in CHO cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed