BDBM50523411 CHEMBL4475207

SMILES CN(C)c1ccc(CNC(=O)[C@H]2CNC[C@@H]2c2ccc(nc2)C(F)(F)F)cc1

InChI Key InChIKey=WXLGXMLWEIXZHQ-SJORKVTESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50523411   

TargetPlasmepsin IV [1-448](Plasmodium falciparum)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523411(CHEMBL4475207)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 4 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523411(CHEMBL4475207)
Affinity DataIC50:  2.17E+4nMAssay Description:Inhibition of Tracer Red binding to human ERG expressed in membranes by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523411(CHEMBL4475207)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523411(CHEMBL4475207)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged BACE1 using Mca-SEVNLDAEFRK(Dpn)RR-NH2 as substrate measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed