BDBM50525283 CHEMBL4458557

SMILES CN1CCN(CC1)c1ccc(Nc2ccc(N3CCCCC3)c(Oc3ccc(C)c(NC(=O)C=C)c3)n2)cc1

InChI Key InChIKey=LTZMKTRBHXYEOB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50525283   

TargetDipeptidyl peptidase 1(Homo sapiens (Human))
National Institute Of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525283(CHEMBL4458557)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of cathepsin C in human THP1 cells using H-Gly-Phe-AFC as substrate preincubated for 4 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
National Institute Of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525283(CHEMBL4458557)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of cathepsin C in human U937 cells using H-Gly-Phe-AFC as substrate preincubated for 4 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
National Institute Of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525283(CHEMBL4458557)
Affinity DataIC50:  18nMAssay Description:Inhibition of CatL-activated recombinant human C-terminal His10-tagged cathepsin C (25 to 463 residues) expressed in mouse myeloma cells using Gly-Ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed