BDBM50542532 CHEMBL4646424

SMILES CC(C)(O)CNC(=O)c1nc(C(=O)N2CCC(F)CC2)c(s1)-c1ccc(c(Cl)c1Cl)S(=O)(=O)N[C@@H](C(C)(C)C)C(F)(F)F

InChI Key InChIKey=SFNXQUTWLUEVKO-QHCPKHFHSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542532   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542532(CHEMBL4646424)
Affinity DataIC50:  8nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542532(CHEMBL4646424)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human RORbeta by thermofluor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542532(CHEMBL4646424)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to human RORgamma LBD by thermofluor thermal shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed