BDBM50542733 CHEMBL4646141

SMILES COc1cccc(C(O)=O)c1OCCc1cc(cc(c1)-c1ccc2OC[C@@H](N)c2c1)C(C)C

InChI Key InChIKey=KXSZMPGKDDBJRE-HSZRJFAPSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50542733   

TargetCoagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  3nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  240nMAssay Description:Inhibition of N-terminal human plasma F11a catalytic domain expressed in Escherichia coli strain BL21(DE3) using D-Leu-Pro-Arg*Rh110-D-Pro as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor VII(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of human F7a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of human F9a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  6.21E+3nMAssay Description:Inhibition of human F10a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibition of human complement FD by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  9nMAssay Description:Inhibition of PKL (unknown origin) using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human tPa using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  3.08E+4nMAssay Description:Inhibition of human plasmin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  400nMAssay Description:Inhibition of human uPA using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542733(CHEMBL4646141)
Affinity DataIC50:  9.09E+3nMAssay Description:Inhibition of human thrombin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed