BDBM50545020 LY-2940680::LY2940680::Taladegib

SMILES CN(C1CCN(CC1)c1nnc(-c2ccnn2C)c2ccccc12)C(=O)c1ccc(F)cc1C(F)(F)F

InChI Key InChIKey=SZBGQDXLNMELTB-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50545020   

TargetSmoothened homolog(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545020(LY-2940680 | LY2940680 | Taladegib)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545020(LY-2940680 | LY2940680 | Taladegib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545020(LY-2940680 | LY2940680 | Taladegib)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) in presence of GDC0449More data for this Ligand-Target Pair