BDBM50545020 LY-2940680::LY2940680::Taladegib
SMILES CN(C1CCN(CC1)c1nnc(-c2ccnn2C)c2ccccc12)C(=O)c1ccc(F)cc1C(F)(F)F
InChI Key InChIKey=SZBGQDXLNMELTB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50545020
Affinity DataIC50: 4.20nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) in presence of GDC0449More data for this Ligand-Target Pair