BDBM50551137 CHEMBL4765125
SMILES CC(C)(C)c1ccc(NC(=O)c2ncn(CC(=O)NCCn3ccc4c(N)ncnc34)n2)cc1
InChI Key InChIKey=XUVUBPKAABPFHR-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50551137
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using histone as substrate i...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 2.48E+5nMAssay Description:Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of recombinant human PRMT8 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 1.65E+5nMAssay Description:Inhibition of recombinant human PRMT5 using histone H2A as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of recombinant human PRMT3 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair