BDBM50555367 CHEMBL4753862

SMILES Cc1cc(NC2CCc3ccc(Br)cc3C2)n2nc(nc2n1)C(C)(F)F

InChI Key InChIKey=WSMWEZWUWJDREU-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50555367   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrate in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50:  1.69E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21 expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50555367(CHEMBL4753862)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed