BDBM50556136 CHEMBL4790634

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4nc(nc5[nH]ncc45)-c4cccnc4)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=JCCUAVDBGXASEC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50556136   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant wild-type human N-terminal GST-HIS6 fused RET C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET M918T mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of KIF5B-RET fusion protein (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804M mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived pe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804L mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed