BDBM50565310 CHEMBL4792981
SMILES C[C@@H](Nc1ccc2[nH]nc(\C=C\c3ccccn3)c2c1)c1cc(F)cc(F)c1
InChI Key InChIKey=ZHOXAGNPCZTRBN-HZRUHFOJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50565310
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TrkA (unknown origin) using Tyr1 peptide as substrate in presence of ATP measured after 2 hrs by FRET-based Z-Lyte kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.90nMAssay Description:Binding affinity to wild-type human partial length TRKC (Q531 to G825 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of TrkC (unknown origin) using Tyr1 peptide as substrate in presence of ATP measured after 2 hrs by FRET-based Z-Lyte kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by Kinomescan method relati...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding affinity to wild-type human partial length ARK5 (E25 to I332 residues) expressed in bacterial expression system by Kinomescan method relative...More data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding affinity to wild-type human full length AURKC (M1 to S275 residues) expressed in bacterial expression system by Kinomescan method relative to...More data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Binding affinity to wild-type human partial length FAK (D402 to R696 residues) expressed in bacterial expression system by Kinomescan method relative...More data for this Ligand-Target Pair
Affinity DataKd: 76nMAssay Description:Binding affinity to wild-type human partial length FGFR1 (P357 to V669 residues) expressed in bacterial expression system by Kinomescan method relati...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:Binding affinity to wild-type human partial length FLT1 (R781 to F1239 residues) expressed in bacterial expression system by Kinomescan method relati...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 190nMAssay Description:Binding affinity to wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 45nMAssay Description:Binding affinity to wild-type human partial length FLT4 (E821 to E1196 residues) expressed in bacterial expression system by Kinomescan method relati...More data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding affinity to wild-type human partial length JAK1 JH1 catalytic domain (V856 to K1154 residues) expressed in bacterial expression system by Kin...More data for this Ligand-Target Pair
Affinity DataKd: 5.5nMAssay Description:Binding affinity to wild-type human partial length JAK2 JH1 catalytic domain (A829 to G1132 residues) expressed in mammalian expression system by Kin...More data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Binding affinity to wild-type human partial length JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system by Kin...More data for this Ligand-Target Pair
TargetMuscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 110nMAssay Description:Binding affinity to wild-type human partial length MUSK (M553 to V869 residues) expressed in bacterial expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 12nMAssay Description:Binding affinity to wild-type human full length PHKG1 (M1 to Y387 residues) expressed in bacterial expression system by Kinomescan method relative to...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 55nMAssay Description:Binding affinity to wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 13nMAssay Description:Binding affinity to wild-type human partial length ROS1 (A1921 to N2240 residues) expressed in bacterial expression system by Kinomescan method relat...More data for this Ligand-Target Pair
Affinity DataKd: 770nMAssay Description:Binding affinity to wild-type human partial length TIE1 (T819 to A1138 residues) expressed in bacterial expression system by Kinomescan method relati...More data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to wild-type human partial length TNK2 (S159 to D474 residues) expressed in bacterial expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University
Curated by ChEMBL
Jinan University
Curated by ChEMBL
Affinity DataKd: 1.60nMAssay Description:Binding affinity to wild-type human partial length TRKA (G475 to G790 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to wild-type human partial length TRKB (Q547 to G838 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of TrkB (unknown origin) using Tyr1 peptide as substrate in presence of ATP measured after 2 hrs by FRET-based Z-Lyte kinase assayMore data for this Ligand-Target Pair