BDBM50570237 CHEMBL4864407
SMILES COc1ncc-2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13
InChI Key InChIKey=IKUIGBXUTOOMRZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50570237
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Inhibition of p110alpha H1047R mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.270nMAssay Description:Inhibition of p110alpha E542K mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.940nMAssay Description:Inhibition of human p110beta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.980nMAssay Description:Inhibition of human p110gamma using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) using LuciferinH-EG as substrate at 10 uM preincubated with enzyme and substrate for 5 mins followed by additi...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using Luciferin-H as substrate at 10 uM preincubated with enzyme and substrate for 5 mins followed by addition ...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using Luciferin-PPXE as substrate at 10 uM preincubated with enzyme and substrate for 5 mins followed by additi...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using Luciferin-ME as substrate at 10 uM preincubated with enzyme and substrate for 5 mins followed by addition...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human GST tagged mTOR (1360 to 2549 residues) expressed in baculovirus expression system measured by LanthaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length p110alpha (1 to 1068 residues) expressed in baculovirus-infected Sf21 cells by ADP-Hunter Plus assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using Luciferin-ME-EG as substrate at 10 uM preincubated with enzyme and substrate for 5 mins followed by addit...More data for this Ligand-Target Pair