BDBM50571460 CHEMBL4858974::US11685734, Example 98

SMILES FC1(F)CCN([C@H]1Cc1ccccc1)c1cc(cc(=O)[nH]1)N1CCOCC1

InChI Key InChIKey=IAQPXVJIBLLKDW-KRWDZBQOSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571460   

TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571460(CHEMBL4858974 | US11685734, Example 98)
Affinity DataKi:  6nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571460(CHEMBL4858974 | US11685734, Example 98)
Affinity DataKi:  39nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571460(CHEMBL4858974 | US11685734, Example 98)
Affinity DataIC50:  920nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571460(CHEMBL4858974 | US11685734, Example 98)
Affinity DataIC50:  38.4nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent