BDBM50572909 CHEMBL4856985

SMILES Cc1coc(n1)-c1cn([C@@H]2O[C@H](COc3ccc4ccc(nc4c3)N3CCC3)[C@@H](O)[C@@H]2F)c2ncnc(N)c12

InChI Key InChIKey=LSEFEXOHUPJOTB-HTCVQUQYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572909   

TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572909(CHEMBL4856985)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572909(CHEMBL4856985)
Affinity DataIC50: <10nMAssay Description:Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed