BDBM50572909 CHEMBL4856985
SMILES Cc1coc(n1)-c1cn([C@@H]2O[C@H](COc3ccc4ccc(nc4c3)N3CCC3)[C@@H](O)[C@@H]2F)c2ncnc(N)c12
InChI Key InChIKey=LSEFEXOHUPJOTB-HTCVQUQYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50572909
TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate...More data for this Ligand-Target Pair