BDBM50578295 CHEMBL4861572

SMILES COCc1ccc(OC(F)(F)F)c(CNC(=O)Nc2c(nc3c(C)nccn23)-c2ccccc2)c1

InChI Key InChIKey=KNZNJSNITSGMNY-UHFFFAOYSA-N

Data  4 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50578295   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human TRKA at inactive state assessed as inhibition of substrate phosphorylation pretreated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataIC50:  11nMAssay Description:Inhibition of human TRKA at inactive state assessed as inhibition of substrate phosphorylation using CSKtide as a substrate pretreated for 20 mins fo...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to human full length TRKA at active state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 52 d...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataIC50:  289nMAssay Description:Inhibition of human TRKB expressed in human U2OS cells assessed as inhibition of substrate hydrolysis pretreated for 30 mins followed by BDNF agonist...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataEC50:  61nMAssay Description:Binding affinity to human full length TRKA at inactive state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 40...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development

Curated by ChEMBL
LigandPNGBDBM50578295(CHEMBL4861572)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human TRKA expressed in human U2OS cells assessed as inhibition of substrate hydrolysis pretreated for 30 mins followed by NGF agonist ...More data for this Ligand-Target Pair