BDBM50579095 CHEMBL4851139
SMILES C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CCCN)NC(=O)[C@@H]1CNC(=O)c2cc3cc(c2)C(=O)N[C@H](Cc2ccc4ccccc4c2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc2ccc4ccccc4c2)C(=O)N[C@@H](c2ccccc2)C(=O)N[C@@H](CCCCNC3=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(N)=O
InChI Key InChIKey=ZQTIVTBIQLGVTK-CMLVFNFRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50579095
Affinity DataIC50: 690nMAssay Description:Inhibition of His6-tagged KRas G12V mutant (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as reduction in Ras/GST-fused Raf ...More data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Binding affinity to GTPgammaS bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to GppNHp bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in MEK phosphorylation preincubated for 4 hrs followed by E...More data for this Ligand-Target Pair
Affinity DataKd: 5.70E+4nMAssay Description:Binding affinity to bovine serum albuminMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in Akt phosphorylation at ser473 residue preincubated for 4...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in Akt phosphorylation at thr308 residue preincubated for 4...More data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding affinity to GDP bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarizationMore data for this Ligand-Target Pair