BDBM50580112 CHEMBL5077748

SMILES Cn1c(N[C@H]2CC[C@H](O)CC2)nc2n(C)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c(=O)c12

InChI Key InChIKey=AZJJYZNRPSOHRZ-JOCQHMNTSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50580112   

TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50580112(CHEMBL5077748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50580112(CHEMBL5077748)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD2 (36 to 350 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB