BDBM50585069 CHEMBL5081210
SMILES COc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCCNS(=O)(=O)c2cccc(F)c2)n1
InChI Key InChIKey=PXCDKWAUSFFTCC-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50585069
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 526nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 111nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 7.98E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 7.58E+3nMAssay Description:Inhibition of NTRK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of HIPK1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of MAPK11 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of MAPK14 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of ZAK (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair